The antiserum was produced against synthesized peptide derived from human PDGF-A. AA range:105-154

PDGF-A Polyclonal Antibody detects endogenous levels of PDGF-A protein.

PDGFA

Platelet-derived growth factor subunit A

PDGFA ;
PDGF1 ;
Platelet-derived growth factor subunit A ;
PDGF subunit A ;
PDGF-1 ;
Platelet-derived growth factor A chain ;
Platelet-derived growth factor alpha polypeptide

platelet derived growth factor subunit A(PDGFA) Homo sapiens This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],

Domain:The long form contains a basic insert which acts as a cell retention signal.,Function:Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.,miscellaneous:A-A and B-B, as well as A-B, dimers can bind to the PDGF receptor.,similarity:Belongs to the PDGF/VEGF growth factor family.,subunit:Antiparallel disulfide-linked dimer of non-identical (A and B) chains. Homodimers of A and B chains are implicated in transformation processes. Interacts with CSPG4.,

Secreted. Released by platelets upon wounding.

PCR rescued clones,

>>EGFR tyrosine kinase inhibitor resistance ;
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>Phospholipase D signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>Gap junction ;
>>JAK-STAT signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>MicroRNAs in cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Choline metabolism in cancer ;
>>Fluid shear stress and atherosclerosis