Catalog: YT0514
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
Bradykinin B1 R
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IF, ELISA
MW
40kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
40kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human BDKRB1. AA range:201-250
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Specificity:
Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.
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Gene Name:
BDKRB1
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Protein Name:
B1 bradykinin receptor
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Other Name:
BDKRB1 ;
BRADYB1 ;
B1 bradykinin receptor ;
B1R ;
BK-1 receptor
BRADYB1 ;
B1 bradykinin receptor ;
B1R ;
BK-1 receptor
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Background:
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
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Function:
Function:This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.,online information:Bradykinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
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Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Tissue Expression:
Lung,Skin,
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Research Areas:
>>Calcium signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Complement and coagulation cascades ;
>>Inflammatory mediator regulation of TRP channels ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer
>>Neuroactive ligand-receptor interaction ;
>>Complement and coagulation cascades ;
>>Inflammatory mediator regulation of TRP channels ;
>>Regulation of actin cytoskeleton ;
>>Pathways in cancer
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Signaling Pathway
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Immune system >> Complement and coagulation cascades
Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels
Human Diseases >> Cancer: overview >> Pathways in cancer
Environmental Information Processing >> Signal transduction >> Calcium signaling pathway
Reference Citation({{totalcount}})
Catalog: YT0514
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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