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XBP1 (PT0319R) PT® Rabbit mAb

-YM8188

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Catalog: YM8188
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

40μL
$190.00
In stock

0

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Main Information
Target

XBP1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat,

Applications

WB, IHC, IF, IP, ELISA

MW

29kD (Calculated)

35kD,60kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200,
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
29kD
MW(Observed)
35kD,60kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0319R
Isotype
IgG,Kappa
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Antigen&Target Information
Sequence:
X-box-binding protein 1
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Specificity:
Endogenous
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Gene Name:
>>Protein processing in endoplasmic reticulum;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases;>>Lipid and atherosclerosis
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Protein Name:
XBP1
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Other Name:
XBP1 ;
TREB5 ;
XBP2 ;
X-box-binding protein 1 ;
XBP-1 ;
Tax-responsive element-binding protein 5
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Database Link:
Organism Gene ID SwissProt
Human 7494; P17861;
Mouse O35426;
Background:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively e
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Function:
Disease:Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature.,Function:Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.,induction:Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,
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Cellular Localization:
Nucleus
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Tissue Expression:
Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856).
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Catalog: YM8188
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

40μL
$190.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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