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Rabbit recombinant genetically engineered antibody

Rabbit recombinant genetically engineered antibody (Rabbit Recombinant Monoclonal Antibodies, RmAbs) Combining the unique advantages of rabbit immune system and modern genetic engineering technology, it has multiple advantages:

 1. High affinity - The immune system of rabbits can produce high affinity antibodies, typically 10 to 100 times more affinity than antibodies produced by mice and other rodents. This makes rabbit recombinant antibodies particularly effective in detecting low abundance targets.

 2. Wide antigen recognition ability - Rabbits have a larger B-cell response pool, which means they can produce more diverse antibodies and recognize a wider range of epitopes. Even antigens that are not immunogenic in mice may produce effective antibodies in rabbits.

3. Higher specificity - Due to the larger and more diverse B-cell response library of rabbits, rabbit recombinant antibodies have an advantage in distinguishing subtle differences such as epitope variations, mutations, and conformational changes. This high specificity reduces the possibility of non-specific binding.

4. Consistency and repeatability - Recombinant technology ensures batch to batch consistency in antibody production. By cloning antibody genes into expression vectors and producing them under controlled cell culture conditions, issues such as drift or gene loss in hybridoma cell lines can be avoided.

5. Stability - Rabbit IgG has fewer amino acids in the N-terminus and D-E loop, and additional disulfide bonds in the variable region of the heavy chain. These structural features make rabbit recombinant antibodies more stable and suitable for long-term storage and use.

6. Multi functional applications - Rabbit recombinant antibodies are suitable for various biological research and clinical applications, including but not limited to:

  -Immunohistochemistry (IHC): Used for protein localization in tissue sections.

  - Western Blot (WB): Used to detect the presence and molecular weight of proteins.

  - Flow cytometry (FCM): used for the analysis of cell surface markers.

  - ELISA: Used for quantitative determination of specific antigens.

  - Research and development of therapeutic antibodies

7. No animal source - recombinant antibodies can be produced in vitro expression systems, avoiding the need for experimental animals and reducing potential contamination risks.

8. Rapid screening and optimization - Through high-throughput screening methods such as phage display technology, the best antibody clones can be quickly screened. In addition, genetic engineering technology allows for further modification and optimization of antibodies to meet specific application requirements.

Immunoway rabbit recombinant genetic engineering antibody It has the advantages of high affinity, high specificity, consistency, and stability, and is a powerful tool for scientific research.