Catalog: YT7990
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
GSDME
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IF, WB, IHC
MW
36kD,55kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IF 1:50-200; WB 1:5000-20000; IHC 1:200-300
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
The antibody detects endogenous full lenth and n-ternal fragment of gsdme protein,
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
36kD,55kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human GSDME. AA range:1-100
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Specificity:
The antibody detects endogenous full lenth and n-ternal fragment of gsdme protein,
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Gene Name:
GSDME
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Protein Name:
Gasdermin-E,DFNA5,Dfna5h,EG14210,2310037D07Rik .4932441K13Rik ,ICERE 1,ICERE-1,Deafness, autosomal dominant 5,Non-syndromic hearing impairment protein 5,GSDME-NT
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Function:
Cleavage at Asp-270 by CASP3 (mature and uncleaved precursor forms) or granzyme B (GZMB) relieves autoinhibition and is sufficient to initiate pyroptosis.
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Cellular Localization:
[Gasdermin-E, N-terminal]: Cell membrane ; Multi-pass membrane protein .; [Gasdermin-E]: Cytoplasm, cytosol .
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Tissue Expression:
Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715).
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT7990
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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