Catalog: YT7374
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
STON2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IF, Flow Cyt, ELISA, IHC
MW
100kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IF/ICC1:50-200; ELISA 1:2000-20000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of STON2 at Human/Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
100kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human STON2 AA range: 47-97
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Specificity:
This antibody detects endogenous levels of STON2 at Human/Mouse
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Gene Name:
STON2 STN2 STNB
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Protein Name:
STON2
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Background:
This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
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Function:
Domain:The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the interaction with the EH domain of SYT1, SYT2, EPS15, EPS15R and ITSN1.,Function:Adapter protein involved in endocytic machinery. May be involved in the vesicle recycling. May facilitate clathrin-coated vesicle uncoating.,similarity:Belongs to the Stoned B family.,similarity:Contains 1 MHD (mu homology) domain.,similarity:Contains 1 SHD (stonin homology) domain.,subcellular location:Some fraction is membrane-associated.,subunit:Interacts with the second C2 domain of synaptotagmins SYT1 and SYT2. Interacts with EPS15, EPS15R and ITSN1. Interacts indirectly with the AP-2 adapter complex.,tissue specificity:Ubiquitous.,
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Cellular Localization:
Cytoplasm . Membrane . Cell junction, synapse, synaptosome . Some fraction is membrane-associated.
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Tissue Expression:
Ubiquitous.
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Reference Citation({{totalcount}})
Catalog: YT7374
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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