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ATG5 (PT0514R) PT® Rabbit mAb

-YM8340

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Catalog: YM8340
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

40μL
$190.00
In stock

0

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Main Information
Target

ATG5

Host Species

Rabbit

Reactivity

Human, Mouse, Rat,

Applications

WB, IHC, IF, IP, ELISA

MW

33kD (Calculated)

55kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
33kD
MW(Observed)
55kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0514R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
ATG5 APG5L ASP
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Protein Name:
ATG5
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Other Name:
Autophagy protein 5 (APG5-like ;
Apoptosis-specific protein)
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Database Link:
Organism Gene ID SwissProt
Human 9474; Q9H1Y0;
Mouse 11793; Q99J83;
Rat Q3MQ06;
Background:
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015],
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Function:
Function:May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.,Function:Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed.,induction:By apoptotic stimuli.,PTM:Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane.,similarity:Belongs to the ATG5 family.,subcellular location:Colocalizes with nonmuscle actin.,tissue specificity:Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.,
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Cellular Localization:
Cytoplasm
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Tissue Expression:
Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells.
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Research Areas:
>>Autophagy - other ;
>>Mitophagy - animal ;
>>Autophagy - animal ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Ferroptosis ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>Shigellosis
show all
Catalog: YM8340
Size
Price
Status
Qty.
200μL
$600.00
In stock

0

100μL
$340.00
In stock

0

40μL
$190.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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