RIG-I-like receptor signaling pathway
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Product List
- DDX58 (PT0686R) PT® Rabbit mAbHuman,MouseWB,IHC,IF,IP,ELISA
- DDX58 Rabbit pAbHuman,MouseWB,ELISA
- MDA5 Rabbit pAbHuman,MouseWB,IHC,IF,ELISA
- MDA5 (Phospho Ser828) Rabbit pAbHuman,Mouse,RatWB
- MAVS Rabbit pAbHuman,Rat,Mouse,WB,ELISA
- DHX58 Rabbit pAbHuman,MouseWB,ELISA
- TRAF3 Rabbit pAbHuman,MouseWB,ELISA
- TANK Rabbit pAbHuman,Mouse,RatWB,IHC,IF,ELISA
- Nap1 Rabbit pAbHuman,Mouse,RatWB,IHC,IF,ELISA
- IKKγ Rabbit pAbHuman,Rat,Mouse,WB,IHC,IF,ELISA
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