Endogenous

LDHA PIG19

L-lactate dehydrogenase A chain (LDH-A) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59)

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008],

Catalytic activity:(S)-lactate + NAD(+) = pyruvate + NADH.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Disease:Defects in LDHA are a cause of exertional myoglobinuria.,online information:Lactate dehydrogenase entry,pathway:Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.,similarity:Belongs to the LDH/MDH superfamily.,similarity:Belongs to the LDH/MDH superfamily. LDH family.,subunit:Homotetramer.,

Cytoplasm

Predominantly expressed in anaerobic tissues such as skeletal muscle and liver.

>>Glycolysis / Gluconeogenesis ;
>>Cysteine and methionine metabolism ;
>>Pyruvate metabolism ;
>>Propanoate metabolism ;
>>Metabolic pathways ;
>>HIF-1 signaling pathway ;
>>Glucagon signaling pathway ;
>>Central carbon metabolism in cancer