The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Mar 2009],
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Function:
similarity:Belongs to the isthmin family.,similarity:Contains 1 AMOP domain.,similarity:Contains 1 TSP type-1 domain.,tissue specificity:Expressed at high levels in the placenta and at moderate levels in the pancreas, kidney, heart, liver, lung, brain and skeletal muscle.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Expressed at high levels in the placenta and at moderate levels in the pancreas, kidney, heart, liver, lung, brain and skeletal muscle.