Catalog: YT0114
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
ADAMTS-16
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
136kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
ADAMTS-16 Polyclonal Antibody detects endogenous levels of ADAMTS-16 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
136kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from ADAMTS-16 . at AA range: 440-520
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Specificity:
ADAMTS-16 Polyclonal Antibody detects endogenous levels of ADAMTS-16 protein.
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Gene Name:
ADAMTS16
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Protein Name:
A disintegrin and metalloproteinase with thrombospondin motifs 16
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Other Name:
ADAMTS16 ;
KIAA2029 ;
A disintegrin and metalloproteinase with thrombospondin motifs 16 ;
ADAM-TS 16 ;
ADAM-TS16 ;
ADAMTS-16
KIAA2029 ;
A disintegrin and metalloproteinase with thrombospondin motifs 16 ;
ADAM-TS 16 ;
ADAM-TS16 ;
ADAMTS-16
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Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016],
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Function:
cofactor:Binds 1 zinc ion per subunit.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 6 TSP type-1 domains.,tissue specificity:Expressed in fetal lung and kidney and in adult prostate and ovary.,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Tissue Expression:
Expressed in fetal lung and kidney and in adult prostate and ovary.
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Reference Citation({{totalcount}})
Catalog: YT0114
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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