Catalog: YP1223
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
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Collected
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Main Information
Target
RIP2 Phospho Ser176
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
61kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This detects endogenous levels of RIPK2 (Phospho-Ser176).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SLsQS
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
61kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
RIP2 Rabbit pAb
YT4147
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Primary Antibodies
RIP2 (Phospho Ser176) Rabbit pAb
YP1223
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Primary Antibodies
RIP2 (Phospho Ser176) Rabbit pAb
YP0797
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ELISA Kits
Total RIPK2 Cell-Based Colorimetric ELISA Kit
KA4270C
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ELISA Kits
RIPK2 (Phospho Ser176) Cell-Based Colorimetric ELISA Kit
KA1721C
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Antigen&Target Information
Immunogen:
Synthesized phospho derived from human RIPK2 (Phospho-Ser176)
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Specificity:
This detects endogenous levels of RIPK2 (Phospho-Ser176).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SLsQS
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Gene Name:
RIPK2 CARDIAK RICK RIP2 UNQ277/PRO314/PRO34092
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Protein Name:
Receptor-interacting serine/threonine-protein kinase 2 (CARD-containing interleukin-1 beta-converting enzyme-associated kinase) (CARD-containing IL-1 beta ICE-kinase) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (Tyrosine-protein kinase RIPK2) (EC 2.7.10.2)
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Other Name:
Receptor-interacting serine/threonine-protein kinase 2 ;
CARD-containing interleukin-1 beta-converting enzyme-associated kinase ;
CARD-containing IL-1 beta ICE-kinase ;
RIP-like-interacting CLARP kinase ;
Receptor-interacting protein 2 ;
RIP-2 ;
Tyrosine-protein kinase RIPK2 ;
CARD-containing interleukin-1 beta-converting enzyme-associated kinase ;
CARD-containing IL-1 beta ICE-kinase ;
RIP-like-interacting CLARP kinase ;
Receptor-interacting protein 2 ;
RIP-2 ;
Tyrosine-protein kinase RIPK2 ;
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Background:
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.,tissue specificity:Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.,
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Cellular Localization:
Cytoplasm .
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Tissue Expression:
Research Areas:
>>NOD-like receptor signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Shigellosis ;
>>Salmonella infection ;
>>Tuberculosis
>>Neurotrophin signaling pathway ;
>>Shigellosis ;
>>Salmonella infection ;
>>Tuberculosis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1223
Size
Price
Status
Qty.
200μL
$936.00
In stock
0
100μL
$560.00
In stock
0
50μL
$300.00
In stock
0
Add to cart
Collected
Collect
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