Catalog: YT5644
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Amphiregulin
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, ELISA
MW
17kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
17kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human AREG/AREGB. AA range:91-140
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Specificity:
Amphiregulin Polyclonal Antibody detects endogenous levels of Amphiregulin protein.
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Gene Name:
AREG/AREGB
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Protein Name:
Amphiregulin
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Other Name:
AREG ;
SDGF ;
AREGB ;
Amphiregulin ;
AR ;
Colorectum cell-derived growth factor ;
CRDGF
SDGF ;
AREGB ;
Amphiregulin ;
AR ;
Colorectum cell-derived growth factor ;
CRDGF
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Database Link:
Background:
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014],
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Function:
Function:Bifunctional growth-modulating glycoprotein. Inhibits growth of several human carcinoma cells in culture and stimulates proliferation of human fibroblasts and certain other tumor cells.,induction:By phorbol 12-myristate 13-acetate (PMA).,miscellaneous:AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.,similarity:Belongs to the amphiregulin family.,similarity:Contains 1 EGF-like domain.,subunit:The immature precursor interacts with CNIH.,
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Cellular Localization:
Membrane; Single-pass membrane protein.
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Tissue Expression:
Brain,Pooled,
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Research Areas:
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hippo signaling pathway ;
>>Colorectal cancer
>>ErbB signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Hippo signaling pathway ;
>>Colorectal cancer
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Signaling Pathway
Human Diseases >> Cancer: specific types >> Colorectal cancer
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Reference Citation({{totalcount}})
Catalog: YT5644
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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