The antiserum was produced against synthesized peptide derived from human KAPCB. AA range:291-340

PKAβ cat Polyclonal Antibody detects endogenous levels of PKAβ cat protein.

PRKACB

cAMP-dependent protein kinase catalytic subunit beta

PRKACB ;
cAMP-dependent protein kinase catalytic subunit beta ;
PKA C-beta

The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by cAMP.,Function:Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.,PTM:Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.,subunit:A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.,tissue specificity:Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoforms 3 and 4 are only epxressed in the brain.,

Cytoplasm . Cell membrane . Membrane ; Lipid-anchor . Nucleus . Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. .

Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.

>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Chemokine signaling pathway ;
>>Oocyte meiosis ;
>>Autophagy - animal ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Wnt signaling pathway ;
>>Hedgehog signaling pathway ;
>>Apelin signaling pathway ;
>>Tight junction ;
>>Gap junction ;
>>Platelet activation ;
>>Circadian entrainment ;
>>Thermogenesis ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>GABAergic synapse ;
>>Dopaminergic synapse ;
>>Olfactory transduction ;
>>Taste transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin signaling pathway ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Ovarian steroidogenesis ;
>>Progesterone-mediated oocyte maturation ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Regulation of lipolysis in adipocytes ;
>>Renin secretion ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Vasopressin-regulated water reabsorption ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Bile secretion ;
>>Parkinson disease ;
>>Prion disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Morphine addiction ;
>>Alcoholism ;
>>Vibrio cholerae infection ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Dilated cardiomyopathy