Catalog: YT2710
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
MEK Kinase-6
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
143kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
143kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330
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Specificity:
MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.
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Gene Name:
MAP3K6
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Protein Name:
Mitogen-activated protein kinase kinase kinase 6
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Other Name:
MAP3K6 ;
ASK2 ;
MAPKKK6 ;
MEKK6 ;
Mitogen-activated protein kinase kinase kinase 6 ;
Apoptosis signal-regulating kinase 2
ASK2 ;
MAPKKK6 ;
MEKK6 ;
Mitogen-activated protein kinase kinase kinase 6 ;
Apoptosis signal-regulating kinase 2
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Background:
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,Function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
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Cellular Localization:
intracellular,
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Tissue Expression:
Brain,PCR rescued clones,Skin,
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Research Areas:
>>MAPK signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2710
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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