Catalog: YN3142
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
SPTC2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of SPTC2 at Human/Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
60kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human SPTC2 AA range: 273-323
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Specificity:
This antibody detects endogenous levels of SPTC2 at Human/Mouse
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Gene Name:
SPTLC2 KIAA0526 LCB2
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Protein Name:
SPTC2
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Other Name:
Serine palmitoyltransferase 2 ;
Long chain base biosynthesis protein 2 ;
LCB 2 ;
Long chain base biosynthesis protein 2a ;
LCB2a ;
Serine-palmitoyl-CoA transferase 2 ;
SPT 2 ;
Long chain base biosynthesis protein 2 ;
LCB 2 ;
Long chain base biosynthesis protein 2a ;
LCB2a ;
Serine-palmitoyl-CoA transferase 2 ;
SPT 2 ;
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Background:
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011],
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Function:
Catalytic activity:Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Lipid metabolism; sphingolipid metabolism.,similarity:Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.,subunit:SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme.,tissue specificity:Widely expressed.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Single-pass membrane protein .
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Tissue Expression:
Widely expressed.
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Research Areas:
>>Sphingolipid metabolism ;
>>Metabolic pathways ;
>>Sphingolipid signaling pathway
>>Metabolic pathways ;
>>Sphingolipid signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN3142
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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