Catalog: YN2369
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
PRLR
Host Species
Rabbit
Reactivity
Human
Applications
WB, ELISA
MW
68kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
PRLR Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
68kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 80-160
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Specificity:
PRLR Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
PRLR
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Protein Name:
Prolactin receptor (PRL-R)
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Background:
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
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Function:
Domain:The box 1 motif is required for JAK interaction and/or activation.,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,Function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
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Cellular Localization:
Membrane ; Single-pass type I membrane protein .; [Isoform 7]: Secreted.
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Tissue Expression:
Expressed in breast, placenta, kidney, liver and pancreas.
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>Neuroactive ligand-receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Prolactin signaling pathway
>>Neuroactive ligand-receptor interaction ;
>>PI3K-Akt signaling pathway ;
>>JAK-STAT signaling pathway ;
>>Prolactin signaling pathway
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Signaling Pathway
Organismal Systems >> Endocrine system >> Prolactin signaling pathway
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YN2369
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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