Catalog: YN2309
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
VMAT2
Host Species
Rabbit
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
MW
56kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
VMAT2 Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
56kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 1-80
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Specificity:
VMAT2 Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
SLC18A2 SVMT VMAT2
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Protein Name:
Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)
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Background:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],
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Function:
Function:Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.,online information:Vesicular monoamine transporter entry,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
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Cellular Localization:
Cytoplasmic vesicle membrane; Multi-pass membrane protein.
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Tissue Expression:
Brain,Platelet,Substantia nigra,Testis,
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Research Areas:
>>Synaptic vesicle cycle ;
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Parkinson disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Parkinson disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN2309
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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