This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008],
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Function:
Function:Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation.,induction:By phytohemagglutinin (PHA).,similarity:Belongs to the LECT2/MIM-1 family.,tissue specificity:Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.,
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Cellular Localization:
Cytoplasm . Secreted .
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Tissue Expression:
Highly expressed in adult and fetal liver and weakly in testis. Not expressed in bone marrow.