Synthesized peptide derived from part region of human protein

PLCB1 Polyclonal Antibody detects endogenous levels of protein.

PLCB1 KIAA0581

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,Function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,

Nucleus membrane . Cytoplasm . Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. .

Brain,Epithelium,Placenta,Testis,

>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Chemokine signaling pathway ;
>>Phosphatidylinositol signaling system ;
>>Sphingolipid signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Wnt signaling pathway ;
>>Apelin signaling pathway ;
>>Gap junction ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>NOD-like receptor signaling pathway ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Long-term depression ;
>>Taste transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Renin secretion ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Cortisol synthesis and secretion ;
>>Parathyroid hormone synthesis, secretion and action ;
>>GnRH secretion ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Cushing syndrome ;
>>Growth hormone synthesis, secretion and action ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Carbohydrate digestion and absorption ;
>>Alzheimer disease ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Chagas disease ;
>>African trypanosomiasis ;
>>Amoebiasis ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis