Catalog: YN0590
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
VMAT1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
57kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
VMAT1 Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
57kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from part region of human protein
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Specificity:
VMAT1 Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
SLC18A1 VAT1 VMAT1
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Protein Name:
Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)
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Background:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008],
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Function:
Function:Involved in the vesicular transport of biogenic amines.,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family.,
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Cellular Localization:
[Isoform 1]: Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein .; [Isoform 2]: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
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Tissue Expression:
Highly expressed in chromaffin cells of the adrenal medulla (at protein level). Detected in peripheral sympathetic ganglia (at protein level). Found in some paracrine cells in stomach and duodenum (at protein level).
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Research Areas:
>>Synaptic vesicle cycle ;
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Parkinson disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
>>Serotonergic synapse ;
>>Dopaminergic synapse ;
>>Parkinson disease ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Alcoholism
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN0590
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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