Synthesized peptide derived from human protein . at AA range: 80-160

ADA Polyclonal Antibody detects endogenous levels of protein.

ADA ADA1

Adenosine deaminase (Adenosine aminohydrolase)

This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008],

Catalytic activity:Adenosine + H(2)O = inosine + NH(3).,Disease:Defects in ADA are the cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-negative/NK-cell-negative due to adenosine deaminase deficiency (ADASCID) [MIM:102700]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients with SCID present in infancy with recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. ADA-SCID is an autosomal recessive form accounting for about 50% of non-X-linked SCIDs. ADA deficiency has been diagnosed in chronically ill teenagers and adults (late or adult onset). Population and newborn screening programs have also identified several healthy individuals with normal immunity who have partial ADA deficiency.,Disease:In hereditary hemolytic anemia, the level of this enzyme in erythrocytes increases 50-70 times.,online information:ADA mutation db,online information:Adenosine deaminase entry,polymorphism:There is a common allele, ADA*2, also known as the ADA 2 allozyme. It is associated with the reduced metabolism of adenosine to inosine. It specifically enhances deep sleep and slow-wave activity (SWA) during sleep.,similarity:Belongs to the adenosine and AMP deaminases family.,tissue specificity:Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues.,

Cell membrane ; Peripheral membrane protein; Extracellular side. Cell junction . Cytoplasmic vesicle lumen . Cytoplasm . Lysosome . Colocalized with DPP4 at the cell surface. .

Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues.

>>Purine metabolism ;
>>Metabolic pathways ;
>>Nucleotide metabolism ;
>>Primary immunodeficiency