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Main Information
Target
TGFB1
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC, WB
MW
52kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC1:50-200; WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of TGF β at Human, Mouse,Rat
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
52kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
1F12
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human TGF β1 Polyclonal
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Specificity:
This antibody detects endogenous levels of TGF β at Human, Mouse,Rat
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Gene Name:
TGFB1 TGFB
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Protein Name:
Transforming growth factor beta-1, TGF-β1, TGF b
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Other Name:
Caspase-3 ;
CASP-3 ;
Apopain ;
Cysteine protease CPP32 ;
CPP-32 ;
Protein Yama ;
SREBP cleavage activity 1 ;
SCA-1 ;
[Cleaved into: Caspase-3 subunit p17 ;
Caspase-3 subunit p12]
CASP-3 ;
Apopain ;
Cysteine protease CPP32 ;
CPP-32 ;
Protein Yama ;
SREBP cleavage activity 1 ;
SCA-1 ;
[Cleaved into: Caspase-3 subunit p17 ;
Caspase-3 subunit p12]
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Database Link:
Background:
Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors.
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Cellular Localization:
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-1]: Secreted .
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Tissue Expression:
Highly expressed in bone (PubMed:11746498, PubMed:17827158). Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) (PubMed:11746498, PubMed:17827158). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage (PubMed:17827158).
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Research Areas:
>>Platinum drug resistance ;
>>MAPK signaling pathway ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Natural killer cell mediated cytotoxicity ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Serotonergic synapse ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Toxoplasmosis ;
>>Amoebiasis ;
>>Tuberculosis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer ;
>>Small cell lung cancer ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis
>>MAPK signaling pathway ;
>>p53 signaling pathway ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Natural killer cell mediated cytotoxicity ;
>>IL-17 signaling pathway ;
>>TNF signaling pathway ;
>>Serotonergic synapse ;
>>Non-alcoholic fatty liver disease ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Pertussis ;
>>Legionellosis ;
>>Toxoplasmosis ;
>>Amoebiasis ;
>>Tuberculosis ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Pathways in cancer ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer ;
>>Small cell lung cancer ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Cell cycle Cellular Processes >> Cell growth and death >> Cellular senescence Organismal Systems >> Immune system >> Th17 cell differentiation Organismal Systems >> Immune system >> Intestinal immune network for IgA production Organismal Systems >> Endocrine system >> Relaxin signaling pathway Organismal Systems >> Development and regeneration >> Osteoclast differentiation Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Cancer: specific types >> Colorectal cancer Human Diseases >> Cancer: specific types >> Pancreatic cancer Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma Human Diseases >> Cancer: specific types >> Gastric cancer Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia Human Diseases >> Cancer: specific types >> Renal cell carcinoma Human Diseases >> Immune disease >> Rheumatoid arthritis Human Diseases >> Immune disease >> Inflammatory bowel disease Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway Environmental Information Processing >> Signal transduction >> Hippo signaling pathway Environmental Information Processing >> Signal transduction >> FoxO signaling pathway Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation(1)
Catalog: YM33051
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200μL
$450.00
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100μL
$280.00
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40μL
$160.00
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