Purified recombinant fragment of human UBC9 expressed in E. Coli.

UBC9 Monoclonal Antibody detects endogenous levels of UBC9 protein.

UBE2I

SUMO-conjugating enzyme UBC9

UBE2I ;
UBC9 ;
UBCE9 ;
SUMO-conjugating enzyme UBC9 ;
SUMO-protein ligase ;
Ubiquitin carrier protein 9 ;
Ubiquitin carrier protein I ;
Ubiquitin-conjugating enzyme E2 I ;
Ubiquitin-protein ligase I ;
p18

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine.,Function:Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with HIPK1, HIPK2 and PPM1J (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TCF3, TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with human adenovirus E1A and human herpesvirus 6 IE2. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B.,tissue specificity:Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.,

Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). .

Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.

>>Nucleocytoplasmic transport ;
>>NF-kappa B signaling pathway ;
>>Ubiquitin mediated proteolysis ;
>>MicroRNAs in cancer