The protein encoded byThis gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence ofThis gene. [provided by RefSeq, Jun 2016]
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Function:
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.,online information:CD2 entry,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with CD2AP (By similarity). Interacts with PSTPIP1.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Detected on umbilical veil endothelial cells (PubMed:162579). Detected in placenta (at protein level) (PubMed:169283). Detected on endothelial cells (PubMed:169283).