ICAM1

Intercellular adhesion molecule 1 ;
ICAM-1 ;
Major group rhinovirus receptor ;
CD antigen CD54 ;

function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,

cell activation, regulation of leukocyte mediated cytotoxicity, adaptive immune response, immune effector process, cell activation during immune response, lymphocyte activation during immune response, T cell activation during immune response, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell,leukocyte activation during immune response, leukocyte mediated immunity, lymphocyte mediated immunity, T cell mediated immunity, T cell antigen processing and presentation, adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, positive regulation of immune system process, regulation of leukocyte migration, positive regulation of leukocyte migration, regulation of cellular extravasation, positive regulation of cellular extravasation, regulation of immune effector process, cell motion, immune response, cell adhesion, heterophilic cell adhesion, leukocyte adhesion, positive regulation of biosynthetic process,viral reproduction, cell-cell adhesion, cell migration, viral infectious cycle, initiation of viral infection, virion attachment to host cell surface receptor, antigen processing and presentation, membrane docking, viral reproductive process,biological adhesion, membrane to membrane docking, regulation of cell adhesion, entry into host cell, regulation of cell migration, positive regulation of cell migration, positive regulation of cellular biosynthetic process, regulation of cell killing, cell adhesion mediated by integrin, regulation of locomotion, positive regulation of locomotion, T cell activation,positive regulation of DNA binding, positive regulation of molecular function, entry into host, leukocyte activation,regulation of nitric oxide biosynthetic process, positive regulation of nitric oxide biosynthetic process, regulation of transcription, lymphocyte activation, entry of virus into host cell, virion attachment, binding of host cell surface receptor, cell motility, leukocyte migration, regulation of transcription factor activity, positive regulation of transcription factor activity, positive regulation of NF-kappaB transcription factor activity, regulation of binding, positive regulation of binding, regulation of DNA binding, positive regulation of nitrogen compound metabolic process, regulation of cell motion, positive regulation of cell motion, localization of cell, interaction with symbiont, entry into cell of other organism during symbiotic interaction, adhesion to other organism during symbiotic interaction, entry into other organism during symbiotic interaction, adhesion to symbiont, movement in host environment, movement in environment of other organism during symbiotic interaction,

Membrane; Single-pass type I membrane protein.