CCNE1

G1/S-specific cyclin-E1

function:Essential for the control of the cell cycle at the G1/S (start) transition.,PTM:Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cyclin family. Cyclin E subfamily.,subunit:Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.,tissue specificity:Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.,

G1/S transition of mitotic cell cycle, mitotic cell cycle, ovarian follicle development, antral ovarian follicle growth, liver development, reproductive developmental process, regulation of transcription, DNA-dependent, cell cycle, intracellular signaling cascade, sex differentiation, response to nutrient, gonad development, female gonad development,response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process,response to extracellular stimulus, response to organic substance, response to organic nitrogen, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, response to organic cyclic substance, response to purine, cell cycle process, cell cycle phase,ovulation cycle process, steroid hormone receptor signaling pathway, androgen receptor signaling pathway,intracellular receptor-mediated signaling pathway, regeneration, organ regeneration, positive regulation of cellular biosynthetic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to nutrient, response to corticosteroid stimulus, response to estradiol stimulus,multicellular organism reproduction, response to progesterone stimulus, response to vitamin E, response to vitamin,response to cytokine stimulus, growth, response to drug, ovulation cycle, response to estrogen stimulus,development of primary sexual characteristics, regulation of transcription, response to ethanol, positive regulation of cell differentiation, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, development of primary female sexual characteristics, female sex differentiation, rhythmic process, response to steroid hormone stimulus,developmental growth, reproductive structure development, reproductive process in a multicellular organism, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, cell division, interphase, interphase of mitotic cell cycle, response to glucocorticoid stimulus, response to mineralocorticoid stimulus, response to corticosterone stimulus,response to methylmercury,

Nucleus .

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.