Synthesized peptide derived from human V-ATPase S1. at AA range: 421-470

V-ATPase S1 Polyclonal Antibody detects endogenous levels of V-ATPase S1

ATP6AP1

V-ATPase S1

V-type proton ATPase subunit S1 ;
V-ATPase subunit S1 ;
Protein XAP-3 ;
V-ATPase Ac45 subunit ;
V-ATPase S1 accessory protein ;
Vacuolar proton pump subunit S1 ;

This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013],

Function:Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the vacuolar ATPase subunit S1 family.,subunit:Composed of at least 10 subunits.,tissue specificity:Ubiquitous.,

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass type I membrane protein . Not detected in trans-Golgi network. .

widely expressed, with highest levels in brain and lowest in liver and duodenum.

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Lysosome ;
>>Phagosome ;
>>Vibrio cholerae infection ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human papillomavirus infection ;
>>Rheumatoid arthritis