Catalog: YT5911
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
NT-3
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
The antibody detects endogenous NT-3
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthetic peptide from human protein at AA range: 180-230
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Specificity:
The antibody detects endogenous NT-3
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Gene Name:
NTF3
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Protein Name:
Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor)
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Other Name:
Neurotrophin-3 ;
NT-3 ;
HDNF ;
Nerve growth factor 2 ;
NGF-2 ;
Neurotrophic factor ;
NT-3 ;
HDNF ;
Nerve growth factor 2 ;
NGF-2 ;
Neurotrophic factor ;
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Background:
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008],
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Function:
Function:Seems to promotes the survival of visceral and proprioceptive sensory neurons.,polymorphism:Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case.,similarity:Belongs to the NGF-beta family.,tissue specificity:Brain and peripheral tissues.,
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Cellular Localization:
Secreted.
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Tissue Expression:
Brain and peripheral tissues.
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Research Areas:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Neurotrophin signaling pathway
>>Ras signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Neurotrophin signaling pathway
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Signaling Pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Reference Citation({{totalcount}})
Catalog: YT5911
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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