Catalog: YT4166
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
RORα
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
RORα Polyclonal Antibody detects endogenous levels of RORα protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
60kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human RORA. AA range:6-55
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Specificity:
RORα Polyclonal Antibody detects endogenous levels of RORα protein.
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Gene Name:
RORA
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Protein Name:
Nuclear receptor ROR-alpha
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Other Name:
RORA ;
NR1F1 ;
RZRA ;
Nuclear receptor ROR-alpha ;
Nuclear receptor RZR-alpha ;
Nuclear receptor subfamily 1 group F member 1 ;
Retinoid-related orphan receptor-alpha
NR1F1 ;
RZRA ;
Nuclear receptor ROR-alpha ;
Nuclear receptor RZR-alpha ;
Nuclear receptor subfamily 1 group F member 1 ;
Retinoid-related orphan receptor-alpha
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Background:
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014],
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Function:
Function:Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Monomer.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Widely expressed in a number of tissues. Expressed in both regulatory T-cells (Treg) and effector T-cells (Teff) (PubMed:18354202, PubMed:7916608). Isoform 4: Highly expressed in the central nervous system, including in the cerebellum (PubMed:29656859).
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Research Areas:
>>Th17 cell differentiation ;
>>Circadian rhythm ;
>>Spinocerebellar ataxia ;
>>Inflammatory bowel disease
>>Circadian rhythm ;
>>Spinocerebellar ataxia ;
>>Inflammatory bowel disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4166
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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