Catalog: YT4051
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Repac
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Repac Polyclonal Antibody detects endogenous levels of Repac protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
60kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human RAPGEF5. AA range:431-480
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Specificity:
Repac Polyclonal Antibody detects endogenous levels of Repac protein.
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Gene Name:
RAPGEF5
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Protein Name:
Rap guanine nucleotide exchange factor 5
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Other Name:
RAPGEF5 ;
GFR ;
KIAA0277 ;
MRGEF ;
Rap guanine nucleotide exchange factor 5 ;
Guanine nucleotide exchange factor for Rap1 ;
M-Ras-regulated Rap GEF ;
MR-GEF ;
Related to Epac ;
Repac
GFR ;
KIAA0277 ;
MRGEF ;
Rap guanine nucleotide exchange factor 5 ;
Guanine nucleotide exchange factor for Rap1 ;
M-Ras-regulated Rap GEF ;
MR-GEF ;
Related to Epac ;
Repac
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Database Link:
Background:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008],
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Function:
Function:Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-GEF domain.,tissue specificity:Widely expressed with highest levels in brain.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Widely expressed with highest levels in brain.
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Research Areas:
>>Ras signaling pathway ;
>>Rap1 signaling pathway
>>Rap1 signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4051
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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