Catalog: YN2692
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
TA2R
Host Species
Rabbit
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
MW
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
TA2R Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
37kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein . at AA range: 230-310
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Specificity:
TA2R Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
TBXA2R
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Protein Name:
Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
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Background:
thromboxane A2 receptor(TBXA2R) Homo sapiens This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
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Function:
Disease:Defects in TBXA2R are the cause of a dominantly inherited bleeding disorder [MIM:188070].,Function:Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase, isoform 2 inhibits adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,
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Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Tissue Expression:
Blood,Endothelial cell,Lung,PCR rescued clones,Placenta,Platelet,
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Research Areas:
>>Calcium signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Platelet activation
>>Neuroactive ligand-receptor interaction ;
>>Platelet activation
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN2692
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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