PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,tissue specificity:Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.,
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Function:
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,tissue specificity:Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.,
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Cellular Localization:
Nucleus . Localizes at sites of DNA damage following replication stress (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (PubMed:27601467, PubMed:27723720). .
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Tissue Expression:
Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.