Endogenous

YES1

Proto-oncogene tyrosine-protein kinase Yes

YES1 ;
YES ;
Tyrosine-protein kinase Yes ;
Proto-oncogene c-Yes ;
p61-Yes

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Function:Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP/CD46.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:In epithelial cells infected with Neisseria gonorrhoeae, forms aggregates beneath bacterial microcolonies.,

Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.

Expressed ubiquitously. Platelets, neurons and osteoclasts express 5-fold to 200-fold higher levels than most other tissues.; [Isoform 1]: Expressed in spleen and liver. ; [Isoform 2]: Expressed in brain. ; [Isoform 3]: Expressed in brain.

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>ErbB signaling pathway ;
>>Rap1 signaling pathway ;
>>Chemokine signaling pathway ;
>>Mitophagy - animal ;
>>Endocytosis ;
>>Axon guidance ;
>>VEGF signaling pathway ;
>>Focal adhesion ;
>>Adherens junction ;
>>Tight junction ;
>>Gap junction ;
>>Platelet activation ;
>>Neutrophil extracellular trap formation ;
>>C-type lectin receptor signaling pathway ;
>>GABAergic synapse ;
>>Inflammatory mediator regulation of TRP channels ;
>>Regulation of actin cytoskeleton ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Prolactin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Relaxin signaling pathway ;
>>Bacterial invasion of epithelial cells ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Yersinia infection ;
>>Tuberculosis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Viral carcinogenesis ;
>>Proteoglycans in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Bladder cancer ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis