Endogenous

CLTC CLH17 CLTCL2 KIAA0034

Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)

TSC2 ;
TSC4 ;
Tuberin ;
Tuberous sclerosis 2 protein

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008],

Function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.,online information:Clathrin entry,similarity:Belongs to the clathrin heavy chain family.,subcellular location:Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1.,

Cytoplasm

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

>>Phospholipase D signaling pathway ;
>>p53 signaling pathway ;
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Cellular senescence ;
>>Thermogenesis ;
>>Insulin signaling pathway ;
>>Thyroid hormone signaling pathway ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Herpes simplex virus 1 infection ;
>>Choline metabolism in cancer