Catalog: YM6987
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
S100
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
11kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; IF 1:50-200; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize human S100B protein, and has a weak reaction with S100A1, but no cross reaction with S100A4 or S100A6.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
11kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT094
Isotype
Mouse IgG2a/Kappa
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S100 (ABT-S100B) Mouse mAb
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human S100 AA range: 2-92
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Specificity:
The antibody can specifically recognize human S100B protein, and has a weak reaction with S100A1, but no cross reaction with S100A4 or S100A6.
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Gene Name:
S100B
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Protein Name:
S100
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Other Name:
Protein S100-B ;
S-100 protein beta chain ;
S-100 protein subunit beta ;
S100 calcium-binding protein B ;
S-100 protein beta chain ;
S-100 protein subunit beta ;
S100 calcium-binding protein B ;
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Background:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells , and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however , this gene is located at 21q22.3. This protein may function in Neurite extension , proliferation of melanoma cells , stimulation of Ca2+ fluxes , inhibition of PKC-mediated phosphorylation , astrocytosis and axonal proliferation , and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological , neoplastic , and other types of diseases , including Alzheimer's disease , Down's syndrome , epilepsy
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Function:
Function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations , especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. ,miscellaneous:In addition to metal-ion binding , this protein is involved with the regulation of protein phosphorylation in brain tissue. ,similarity:Belongs to the S-101 family. ,similarity:Contains 2 EF-hand domains. ,subunit:Dimer of either two alpha chains , or two beta chains , or one alpha and one beta chain. The S100B dimer binds two molecules of STK38 (By similarity) . The S100B dimer interacts with two molecules of CAPZA1. ,tissue specificity:Although predominant among the water-soluble brain proteins , S100 is also found in a variety of other tissues. ,
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Cellular Localization:
Nuclear , Cytoplasmic
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YM6987
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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