Catalog: YM6955R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
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Main Information
Target
Glypican-3
Host Species
Mouse
Reactivity
Human
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
Ready to use for IHC
Formulation
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Specificity
The antibody can specifically recognize human Glypican-3 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT180
Isotype
Mouse IgG1/Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Glypican-3(GPC3) AA range: 400-500
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Specificity:
The antibody can specifically recognize human Glypican-3 protein.
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Gene Name:
GPC3 OCI5
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Protein Name:
Glypican-3 (GPC3)
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Other Name:
Glypican-3 ;
GTR2-2 ;
Intestinal protein OCI-5 ;
MXR7 ;
[Cleaved into: Secreted glypican-3]
GTR2-2 ;
Intestinal protein OCI-5 ;
MXR7 ;
[Cleaved into: Secreted glypican-3]
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Background:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26 , and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome , also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Sep 2009] ,
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Function:
Disease:Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS) . SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies. ,Function:Cell surface proteoglycan that bears heparan sulfate. ,Function:Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition. ,similarity:Belongs to the glypican family. ,tissue specificity:Highly expressed in lung , liver and kidney. ,
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Cellular Localization:
Cytoplasmic
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Tissue Expression:
Research Areas:
>>Proteoglycans in cancer
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Reference Citation({{totalcount}})
Catalog: YM6955R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
Add to cart
Collected
Collect
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