Catalog: YM6918R
Size
Price
Status
Qty.
10mL
$240.00
In stock
0
6mL
$180.00
In stock
0
3mL
$120.00
In stock
0
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Main Information
Target
Vimentin
Host Species
Mouse
Reactivity
Human, Mouse, Rat,
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
Ready to use for IHC
Formulation
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Specificity
The antibody can specifically recognize human Vimentin protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT281
Isotype
IgG1,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Vimentin AA range: 400-466
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Specificity:
The antibody can specifically recognize human Vimentin protein.
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Gene Name:
VIM
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Protein Name:
Vimentin
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Other Name:
Vimentin
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Background:
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009],
Function:
Function:Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.,online information:Vimentin entry,PTM:One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized.,sequence Caution:Intron retention.,similarity:Belongs to the intermediate filament family.,subunit:Homopolymer. Interacts with HCV core protein. Interacts with LGSN and SYNM.,tissue specificity:Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.,
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Cellular Localization:
Cytoplasmic
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Tissue Expression:
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
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Research Areas:
>>Epstein-Barr virus infection ;
>>MicroRNAs in cancer
>>MicroRNAs in cancer
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Signaling Pathway
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Catalog: YM6918R
Size
Price
Status
Qty.
10mL
$240.00
In stock
0
6mL
$180.00
In stock
0
3mL
$120.00
In stock
0
Add to cart
Collected
Collect
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