Catalog: YM6893
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
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Collected
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Main Information
Target
MUM1
Host Species
Mouse
Reactivity
Human,
Applications
IHC, ELISA
MW
52kD (Calculated)
52kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize human MUM1 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
52kD
MW(Observed)
52kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT080
Isotype
IgG1,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human MUM1 AA range: 350-451
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Specificity:
The antibody can specifically recognize human MUM1 protein.
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Gene Name:
IRF4 MUM1
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Protein Name:
MUM1
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Other Name:
Interferon regulatory factor 4 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
IRF-4 ;
Lymphocyte-specific interferon regulatory factor ;
LSIRF ;
Multiple myeloma oncogene 1 ;
NF-EM5 ;
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Background:
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
Function:
Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
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Cellular Localization:
Nuclear
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Tissue Expression:
Lymphoid cells.
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Research Areas:
>>Th17 cell differentiation
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6893
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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