Catalog: YM6859R
Size
Price
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10mL
$240.00
In stock
0
6mL
$180.00
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0
3mL
$120.00
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Main Information
Target
Cytokeratin 15
Host Species
Mouse
Reactivity
Human,
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
Ready to use for IHC
Formulation
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Specificity
The antibody can specifically recognize human CK15 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels the squamous epithelial cells and carcinomas, and shows no reaction with glandular epithelial cells.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT058
Isotype
IgG1,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human CK15 AA range: 350-456
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Specificity:
The antibody can specifically recognize human CK15 protein. In immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections, the antibody specifically labels the squamous epithelial cells and carcinomas, and shows no reaction with glandular epithelial cells.
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Gene Name:
KRT15 KRTB
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Protein Name:
Cytokeratin-15
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Other Name:
Keratin, type I cytoskeletal 15 ;
Cytokeratin-15 ;
CK-15 ;
Keratin-15 ;
K15 ;
Cytokeratin-15 ;
CK-15 ;
Keratin-15 ;
K15 ;
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Background:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008],
Function:
miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.,
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Cellular Localization:
Cytoplasmic, Membranous
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Tissue Expression:
Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.
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Research Areas:
>>Estrogen signaling pathway ;
>>Staphylococcus aureus infection
>>Staphylococcus aureus infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6859R
Size
Price
Status
Qty.
10mL
$240.00
In stock
0
6mL
$180.00
In stock
0
3mL
$120.00
In stock
0
Add to cart
Collected
Collect
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