Catalog: YM6684
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
Arginase I
Host Species
Mouse
Reactivity
Human
Applications
IHC, ELISA
MW
35kD (Calculated)
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize human Arginase-1 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
35kD
MW(Observed)
37kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-Arg1
Isotype
Mouse IgG2b/Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Arginase-1 AA range: 200-322
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Specificity:
The antibody can specifically recognize human Arginase-1 protein.
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Gene Name:
ARG1
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Protein Name:
Arginase-1 (Liver-type arginase) (Type I arginase)
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Background:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution , subcellular localization , immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene , is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia , an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Sep 2011] ,
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Function:
Catalytic activity:L-arginine + H (2) O = L-ornithine + urea. ,cofactor:Binds 2 manganese ions per subunit. ,Disease:Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid , and periodic hyperammonemia occurs. Clinical manifestations include developmental delay , seizures , mental retardation , hypotonia , ataxia , progressive spastic quadriplegia. ,induction:By arginine or homoarginine. ,online information:Arginase entry ,pathway:Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. ,similarity:Belongs to the arginase family. ,subunit:Homotrimer. ,
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Cellular Localization:
Nuclear , Cytoplasmic
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Research Areas:
>>Arginine biosynthesis ;
>>Arginine and proline metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Amoebiasis
>>Arginine and proline metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Amoebiasis
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Reference Citation({{totalcount}})
Catalog: YM6684
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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