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Actin, smooth muscle (SMA) (ABT-SMA) mouse mAb

-YM6566

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Main Information
Target

Actin_smooth muscle (SMA)

Host Species

Mouse

Reactivity

Human, Mouse, Rat,

Applications

IHC, ELISA

MW

42kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize smooth muscle actin and shows no reaction with actin of skelatal muscle or cardiac muscle.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Observed)
42kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-SMA
Isotype
IgG2a,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Actin, smooth muscle (SMA) AA range: 1-100
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Specificity:
The antibody can specifically recognize smooth muscle actin and shows no reaction with actin of skelatal muscle or cardiac muscle.
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Gene Name:
Actin, smooth muscle
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Protein Name:
Actin, smooth muscle
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Database Link:
Organism Gene ID SwissProt
Human P62736;P63267;
Background:
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
Function:
Disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.,
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Cellular Localization:
Cytoplasmic
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Tissue Expression:
Pituitary,Uterus,
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Research Areas:
>>Vascular smooth muscle contraction ;
>>Apelin signaling pathway ;
>>Relaxin signaling pathway
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Reference Citation(1)
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Catalog: YM6566
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$340.00
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40μL
$190.00
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