Catalog: YM6546
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
Sox-9
Host Species
Mouse
Reactivity
Human, Mouse, Rat, Bovine
Applications
IHC, ELISA
MW
56kD (Calculated)
70kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize human SOX9 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
56kD
MW(Observed)
70kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-SOX9
Isotype
Mouse IgG2b/Kappa
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SOX9 (ABT-SOX9) Mouse mAb (Ready to Use)
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SOX9 (Phospho Ser181) Rabbit pAb
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Primary Antibodies
SOX9 (ABT-SOX9) Mouse mAb
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Total SOX9 Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human SOX9 AA range: 1-100
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Specificity:
The antibody can specifically recognize human SOX9 protein.
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Gene Name:
SOX9
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Protein Name:
Transcription factor SOX-9
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Background:
SRY-box 9 (SOX9) Homo sapiens The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and , with steroidogenic factor 1 , regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia , frequently with sex reversal. [provided by RefSeq , Jul 2008] ,
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Function:
Disease:Defects in SOX9 are the cause of campomelic dysplasia (CMD1) [MIM:114290]. CMD1 is a rare , often lethal , dominantly inherited , congenital osteochondrodysplasia , associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones , unusually small scapulae , deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate , micrognatia , flat face and hypertelorism are common. Various defects of the ear are often evident , affecting the cochlea , malleus incus , stapes and tympanum. Most patients die soon after birth due to respiratory distress which has been attributed to hypoplasia of the tracheobronchial cartilage and small thoracic cage. ,Function:Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. ,similarity:Contains 1 HMG box DNA-binding domain. ,
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Cellular Localization:
Nuclear
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Tissue Expression:
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Research Areas:
>>cAMP signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6546
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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