Catalog: YM6178R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
Add to cart
Collected
Collect
Main Information
Target
Fascin
Host Species
Mouse
Reactivity
Human, Mouse, Rat
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
Ready to use for IHC
Formulation
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Specificity
The antibody can specifically recognize human Fascin protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-FASN
Isotype
Mouse IgG1/Kappa
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
More→
Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Fascin AA range: 250-350
show all
Specificity:
The antibody can specifically recognize human Fascin protein.
show all
Gene Name:
FSCN1 FAN1 HSN SNL
show all
Protein Name:
Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)
show all
Database Link:
Background:
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles , and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration , motility , adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs , and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq , Sep 2011] ,
show all
Function:
Disease:Marks and mediates breast cancer metastasis to the lungs. FSCN1 is not functionally validated but achieves the highest statistical significance (P less than 0.000001) . Those subjects expressing the lung metastasis signature have a significantly poorer lung metastasis-free survival , but not bone metastasis-free survival , compared to subjects without the signature. ,Function:Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Probably involved in the assembly of actin filament bundles present in microspikes , membrane ruffles , and stress fibers. ,PTM:Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. ,similarity:Belongs to the fascin family. ,subunit:Associates with beta-catenin. ,tissue specificity:Ubiquitous. ,
show all
Cellular Localization:
Cytoplasmic
show all
Tissue Expression:
show all
Research Areas:
>>MicroRNAs in cancer
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6178R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}