Catalog: YM6120R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
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Collected
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Main Information
Target
HDAC6
Host Species
Mouse
Reactivity
Human, Mouse
Applications
IHC
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
Ready to use for IHC
Formulation
The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Specificity
The antibody can specifically recognize human HDAC6 protein.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
2°C to 8°C/1 year,Ship by ice bag
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT-HDAC6
Isotype
Mouse IgG1/Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human HDAC6 AA range: 1100-1215
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Specificity:
The antibody can specifically recognize human HDAC6 protein.
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Gene Name:
HDAC6 KIAA0901 JM21
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Protein Name:
Histone deacetylase 6 (HD6) (EC 3.5.1.98)
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Background:
Histones play a critical role in transcriptional regulation , cell cycle progression , and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq , Jul 2008] ,
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Function:
Catalytic activity:Hydrolysis of an N (6) -acetyl-lysine residue of a histone to yield a deacetylated histone. ,Function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A , H2B , H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation , cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity) . Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. ,PTM:Sumoylated in vitro. ,PTM:Ubiquitinated. Its polyubiquitination however does not lead to its degradation. ,similarity:Belongs to the histone deacetylase family. Type 2 subfamily. ,similarity:Contains 1 UBP-type zinc finger. ,subcellular location:It is mainly cytoplasmic , where it is associated with microtubules. ,subunit:Interacts with CBFA2T3 , HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. ,
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Cellular Localization:
Cytoplasmic
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Tissue Expression:
Research Areas:
>>Neutrophil extracellular trap formation ;
>>Amyotrophic lateral sclerosis ;
>>Alcoholism ;
>>Viral carcinogenesis
>>Amyotrophic lateral sclerosis ;
>>Alcoholism ;
>>Viral carcinogenesis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM6120R
Size
Price
Status
Qty.
10mL
$150.00
3 weeks
0
6mL
$120.00
3 weeks
0
3mL
$70.00
3 weeks
0
Add to cart
Collected
Collect
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