Synthesized peptide derived from human BOB.1 AA range: 150-256

The antibody can specifically recognize human BOB.1 protein.

POU2AF1 OBF1

POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (BOB-1) (OCA-B) (OCT-binding factor 1)

B cell Oct binding protein 1 ;
B cell specific coactivator OBF 1 ;
B cell specific coactivator OBF1 ;
B-cell-specific coactivator OBF-1 ;
BOB 1 ;
BOB-1 ;
OBF 1 ;
OBF1 ;
OBF1_HUMAN ;
OCA B ;
OCA-B ;
OCAB ;
OCT binding factor 1 ;
OCT-binding factor 1 ;
POU class 2 associating factor 1 ;
POU domain class 2 associating factor 1 ;
POU domain class 2-associating factor 1 ;
Pou2af1

BOB.1 is a transcription activating factor necessary for the formation of follicular germinal center and the production of immunoglobulin. It works together with Oct-2 and is highly expressed in granulocytes of spleen and peripheral blood. It is mainly used for the typing of Hodgkin's lymphoma , mainly nodular lymphocytes. Hodgkin's lymphoma is positive and classical Hodgkin's lymphoma is negative.

Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with BCL6. ,Function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent , that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. ,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. ,similarity:Belongs to the POU2AF1 family. ,tissue specificity:B-cell specific. ,

Nuclear , Cytoplasmic