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Cytokeratin 7 (ABT436) mouse mAb

-YM6056

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Main Information
Target

Cytokeratin 7

Host Species

Mouse

Reactivity

Human,

Applications

IHC, ELISA

MW

51kD (Calculated)

51kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
IHC 1:200-400; ELISA 1:500-5000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
The antibody can specifically recognize human CK7 protein, and shows no cross reaction with CK1, 4, 5, 6, 8, 10, 14, 17, 18, 19, 20.
Purification
The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
51kD
MW(Observed)
51kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
ABT436
Isotype
IgG1,Kappa
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human Cytokeratin 7 AA range: 350-469
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Specificity:
The antibody can specifically recognize human CK7 protein, and shows no cross reaction with CK1, 4, 5, 6, 8, 10, 14, 17, 18, 19, 20.
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Gene Name:
KRT7 SCL
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Protein Name:
CK 7;CK-7;CK7;Cytokeratin 7;Cytokeratin-7;D15Wsu77e;K2C7;K2C7_HUMAN;K7;Keratin 7;Keratin 7, type II;Keratin type II cytoskeletal 7;Keratin, 55K type II cytoskeletal;Keratin, simple epithelial;Keratin, simple epithelial type I, K7;Keratin, type II cytoskeletal 7;Keratin-7;Krt2-7;KRT7;MGC11625;MGC129731;MGC3625;Sarcolectin;SCL;Type II mesothelial keratin K7;Type-II keratin Kb7
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Other Name:
CK 7 ;
CK-7 ;
CK7 ;
Cytokeratin 7 ;
Cytokeratin-7 ;
D15Wsu77e ;
K2C7 ;
K2C7_HUMAN ;
K7 ;
Keratin 7 ;
Keratin 7, type II ;
Keratin type II cytoskeletal 7 ;
Keratin, 55K type II cytoskeletal ;
Keratin, simple epithelial ;
Keratin, simple epithelial type I, K7 ;
Keratin, type II cytoskeletal 7 ;
Keratin-7 ;
Krt2-7 ;
KRT7 ;
MGC11625 ;
MGC129731 ;
MGC3625 ;
Sarcolectin ;
SCL ;
Type II mesothelial keratin K7 ;
Type-II keratin Kb7
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Database Link:
Organism Gene ID SwissProt
Human 3855; P08729;
Mouse Q9DCV7;
Rat Q6IG12;
Background:
keratin 7(KRT7) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Function:
Function:Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).,induction:Up-regulated by retinoic acid.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Arg-20 is dimethylated, probably to asymmetric dimethylarginine.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.,tissue specificity:Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.,
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Cellular Localization:
Cytoplasmic, Membranous
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Tissue Expression:
Pancreas
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Reference Citation(1)
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Catalog: YM6056
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