Purified recombinant Human CD137

This recombinant monoclonal antibody can detects endogenous levels of CD137/4-1BB protein.

TNFRSF9 CD137 ILA

Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)

TNFRSF9 ;
CD137 ;
ILA ;
Tumor necrosis factor receptor superfamily member 9 ;
4-1BB ligand receptor ;
CDw137 ;
T-cell antigen 4-1BB homolog ;
T-cell antigen ILA ;
CD antigen CD137

The protein encoded byThis gene is a member of the TNF-receptor superfamily.This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression ofThis receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind toThis receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Receptor for TNFSF14/4-1BBL. Possibly active during T cell activation.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.,tissue specificity:Expressed on the surface of activated T-cells.,

Membrane; Single-pass type I membrane protein.

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.