Purified recombinant Human CD142

This recombinant monoclonal antibody can detects endogenous levels of CD142 protein.

F3

Tissue factor (TF) (Coagulation factor III) (Thromboplastin) (CD antigen CD142)

Coagulation Factor III ;
Tissue Factor ;
TF ;
Thromboplastin ;
platelet tissue factor ;
factor III ;
factor 3 ;
F3 ;
F-3 ;
TFA

CD142, also known as Tissue Factor (TF), Coagulation Factor III, and Thromboplastin, is a 45 kD type I transmembrane glycoprotein. It is expressed on the surface of a variety of cells that are physically separated from the circulating blood which include smooth muscle cells, fibroblasts, keratinocytes, glomerular epithelial cells (cytoplasmic inclusions), astrocytes, myocardium, liver stromal cells, pancreas cells, and is also expressed on activated monocytes and stimulated endothelial cells. CD142 is a high-affinity receptor for coagulation factor VII and initiates the extrinsic pathway of blood coagulation. CD142 also plays an important role in a variety of diseases such as sepsis, atherosclerosis, and cancer.

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

[Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Lung, placenta and pancreas.