TGFA

Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ;
TGF-alpha ;
EGF-like TGF ;
ETGF ;
TGF type 1 ;
]

function:TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.,similarity:Contains 1 EGF-like domain.,subunit:Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2.,

MAPKKK cascade, activation of MAPK activity, angiogenesis, blood vessel development, vasculature development,protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, regulation of mitosis, regulation of epidermal growth factor receptor activity, intracellular signaling cascade, protein kinase cascade,regulation of mitotic cell cycle, cell proliferation, positive regulation of cell proliferation, positive regulation of signal transduction, regulation of receptor activity, regulation of cell cycle process, positive regulation of organelle organization, positive regulation of cell communication, phosphorylation, regulation of phosphate metabolic process,regulation of organelle organization, positive regulation of kinase activity, regulation of epidermal growth factor receptor signaling pathway, regulation of cell proliferation, regulation of phosphorylation, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, positive regulation of epidermal growth factor receptor activity,positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of cell cycle, positive regulation of mitosis, regulation of protein kinase activity, positive regulation of protein kinase activity, blood vessel morphogenesis, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of cellular component organization, regulation of phosphorus metabolic process, regulation of cell division,regulation of transferase activity, positive regulation of transferase activity, regulation of cell cycle, positive regulation of cell division, regulation of nuclear division, positive regulation of nuclear division,

[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.

Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.